Nifedipine for tocolysis

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Nifedipine for tocolysis.

The release of the new WHO recommendations (October, 2015) for preterm birth interventions is welcome. With regard to the place of tocolysis, the guidelines present a balanced view of the current uncertainties and indicate a preference for nifedipine as the drug of choice when tocolysis is considered, while emphasising the need for further research. However, an important issue in the availabili...

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Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial.

IMPORTANCE In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome. OBJECTIVE To determine whether maintenance tocolysis with nifedipine will reduce adverse perinatal outcomes due to premature birth. DESIGN, SETTING, AND PARTICIPANTS APOSTEL-II (Assessment of Perinatal Outcome wi...

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The Essence of Tocolysis

Preterm birth, defined as birth before 37 weeks gestation, is a major contributor to perinatal morbidity and mortality. It occurs in 12,000 pregnancies in the Netherlands per year. Of all perinatal mortality, 50-70% can be attributed to preterm birth. Preterm birth can be iatrogenic due to the condition of the mother or the child, but the majority occurs spontaneously, either starting with pret...

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The Evidence Regarding Maintenance Tocolysis

Preterm delivery is a public health issue of major proportion. More than 12% of deliveries in the United States that occur at less than 37 weeks gestation preterm labor (PTL) represents the largest single reason for preterm birth (PTB). Attempts to prevent PTB have been unsuccessful. This paper of maintenance tocolytic therapy will examine the efficacy and safety of the drugs, both oral and sub...

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Effectiveness of Heparin during Long-Term Tocolysis

Objective. Drip infusion during long-term tocolysis causes mechanical and infectious vasculitis and increases the frequency of peripheral venous catheter exchange (PVC), thereby placing a burden on patients. Our study aim is to confirm whether heparin ameliorates pain due to vasculitis during long-term tocolysis and reduces the frequency of peripheral venous catheter exchange. Design. Prospecti...

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ژورنال

عنوان ژورنال: The Lancet Global Health

سال: 2016

ISSN: 2214-109X

DOI: 10.1016/s2214-109x(15)00214-4